2010 数理モデルを用いた細胞質分裂における細胞表層の力学の時空間的変化の予測(OS20. 細胞・生体分子の計算バイオメカニクス(2),オーガナイズドセッション講演)

概要

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Cytokinesis is the final process of cell division, in which a cell body is mechanically separated into two daughter cells. The changes in cell shape are regulated by not only the actomyosin contractile ring but also global cell-surface mechanics whose properties are predominantly provided from cytoskeleton. The spatial and temporal dynamics of cell-surface mechanics and its underlying regulatory mechanisms, however, are not well understood. It is technically difficult to directly measure cell-surface mechanical parameters with high spatio-temporal resolution. Here, we are trying to construct an indirect method for predicting the spatio-temporal dynamics of the mechanical parameters in which experimentally observed cell shapes and mathematical models are employed. By using this method, we are predicting spatio-temporal change in bending modulus, an index of cell-surface stiffness. We will also discuss the application of this method for illuminating the mechanisms conferring morphological phenotypes in various cvtokinesis mutant cells.
一般社団法人日本機械学会の論文
2010-09-23