2013 線虫C. elegans初期胚の細胞質流動の粒子法シミュレーションを通した細胞質のレオロジーの理解(OS20.細胞・生体分子の計算バイオメカニクス(4),オーガナイズドセッション)

概要

論文の詳細を見る
The streaming of cytoplasmic materials, or the cytoplasm, in the cells is called cytoplasmic streaming. Since cytoplasmic streaming is widely seen and has various physiological roles, understanding its mechanics has a great significance in cell biology. One of the competent approaches to understand the mechanics of cytoplasmic streaming is fluid dynamics simulation. However, what kinds of the rheological model adequately describe the fluid dynamics of the cytoplasm is largely unknown. Especially, fluid dynamics in sphere-like shaped cells has not been researched through comparison of experiment and theory. Here, we conducted comparison between fluid dynamics in C. elegans embryo and MPS (Moving Particle Semi-implicit Method) or DEM (Distinct Element Method) simulations. We find that both of the simulations roughly reconstitute the fluid dynamics in vivo captured by our microscopy. The success of MPS description suggests that Newtonian fluid model can explain fluid dynamics in the cells. The success of DEM description as well as MPS description suggests that we can roughly predict the fluid dynamics in the cells with some wide range of rheological models of the cytoplasm.
一般社団法人日本機械学会の論文
2009-10-10