T0201-1-2 せん断応力下での細胞膜構造変化 : 分子シミュレーション([T0201-1]細胞の構造と流れにおけるマイクロ・ナノスケール解析(1))

概要

論文の詳細を見る
Structural changes of the cell membrane under shear stresses are investigated by means of molecular dynamics simulations. The cell membrane is modeled as a binary bilayer composed of palmitoyloleoylphosphatidylcholine (POPC) and cholesterol molecules, where the cholesterol concentration is similar to red blood cell's membrane (〜40%). The area per lipid of the binary bilayer is smaller than a pure POPC bilayer, indicating the hydrophobic chains of the lipid become ordered with the inclusion of cholesterol. Shear stresses are imposed by the momentum change of a slab of water molecules adjacent to one side of the bilayer. We found that under shear stresses, the inclusion of cholesterol molecules impairs the deformation of POPC molecules in the bilayer normal direction, whereas it enhances the tilt of POPC molecules.
一般社団法人日本機械学会の論文
2010-09-04