亜硫酸ナトリウムのCandida Glabrata傷害作用
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When Candida Glabrata was cultured with sodium sulfite,the growth was inhibited and the cells were enlarged.Scanning electron microscopy (SEM) analyses indicated that the surface of C.glabrata treated by sodium sulfite appeared to be rough.The cell strength C.glabrata treated by sodium sulfite was lower than of untreated cells.Transmission electron microscopy (TEM) analyses showed that the cell wall components might be decreased by sodium sulfite.Sodium sulfite inhibited the expression of mRNAs which encoded 1,3-β-D-glican synthase and α1.6-mannnosyl-transferase, but not chitin synthase.These findings indicated that sodium sulfite inhibited the construction of cell wall by inhibiting 1,3-β-D-glican synthase and α1.6-mannnosyl-transferase.Thus,C.glabrata become fragile by treatment with sodium sulfate.
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