Influences of the Grifola Gargal extracts on insulin resistance induced by high-fructose diet in rats

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It has been well known that the high fructose diet causes the insulin resistance. And it has beenreported that certain components of mushrooms effects on insulin resistance. The purpose of this studywas to evaluate the effects of Grifola Gargal (mushroom) extracts on insulin resistance induced by highfructosediet. Male rats of strain aged 7 weeks were divided into 3 groups, such as high-fructose diet(Fru), high-fructose diet + Grifola Gargal extracts (1.5% in diet; Fru + G), and standard chow-diet(Control) groups. For these rats, after one overnight fasts, a sequential euglycemic clamp experimentwith two different insulin infusion rates of 3.0 (L-clamp) and 30.0 mU/kg BW/min (H-clamp) wasperformed. Glucose infusion rates (GIRs), calculated respectively from 60 to 90 min in L-clamp, and150 to 180 min in H-clamp, were recognized an sign of whole body insulin action. High-fructose feedingmarkedly reduced GIRs in both L- and H-clamp experiments compared with Control. In L-clampexperiment, the effects of Grifola Gargal extracts were not shown. However, in H-clamp, GIR wereincreased by Grifola Gargal extracts compared with Fru, and reached the same levels as in Control.Therefore, we demonstrated that the administration of Grifola Gargal extracts did not affect insulinsensitivity, but produced a significant rise in insulin responsiveness.
2011-03-31