M6-4 一塩基分解能を有する粗視化DNAモデルの開発と電気泳動解析(M6 バイオセンサ・システム)

概要

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In the present study, we develop a coarse graining model of dsDNA sequences which has single nucleotide resolution. The model based on a bead spring system and further interactions well agree with experimental results of the melting temperature and bending characteristics. Furthermore, in order to investigate electronic characteristics of DNA fragments, we develop an analytical model which treats electron transport via a point contact between molecules and prove electrodes. In the theoretical model, the electron transport is treated based on quantum theory because of the nano scale phenomena. The present result qualitatively explains the electron transport characteristics observed through a metallic nano particle. Further development is expected to apply this theoretical model to DNA sequencing.
一般社団法人日本機械学会の論文
2009-10-15