T0502-3-3 透明性微小電極を用いた生体高分子のナノ流動制御(マイクロ・ナノ領域におけるバイオ・熱流体の融合学術創成(3))

概要

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In the present study, we developed a numerical scheme to analyze the flow dynamics of biomacromolecules in a nanochannel. To include the effect of electric double layer near the wall, the electric field and the distribution of ions are modeled by the Poisson equation and the Boltzmann distribution, respectively. On the other hand, the biomacromolecule is described by the bead-spring model. The flow dynamics of 1μm long DNA in a rectangular nanochannel of 80×80 nm is analyzed based on the Langevin equation. The numerical result shows that the DNA model is extended along the longitudinal direction of nanochannel due to the electric field in the electric double layer. The characteristic time for the extension increases with the ionic concentration. Furthermore, a simple theoretical model for predicting the characteristic time is also presented. Consequently, the applicability of nanochannel for the measurement of biomacromolecule is confirmed.
社団法人日本機械学会の論文
2009-09-12