Bioconversion of the antihistaminc drug loratadine by tobacco cell suspension cultures expressing human cytochrome P450 3A4(PLANT BIOTECHNOLOGY)

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概要

• 論文の詳細を見る

• In this study we have expanded the metabolic potential of plant cell suspension cultures by introducing active human cytochrome P450 monooxygenase 3A4 into tobacco cells. Exogenously supplied loratadine was metabolized in a 3A4-specific manner, showing the capacity of this system for the generation of metabolites.

著者

• Unger Matthias

  Institut Fur Pharmazie Und Lebensmittelchemie Julius-maximilians Universitat

• Warzecha Heribert

  Technische Universitaet Darmstadt, Department for Biology

• Ferme Daniela

  Institut fur Pharmazie und Lebensmittelchemie, Julius-Maximilians Universitat

• Peer Markus

  Julius-von-Sachs-Institut, Julius-Maximilians Universitat

• Frank Andreas

  Institut fur Pharmazie und Lebensmittelchemie, Julius-Maximilians Universitat

• Ferme Daniela

  Institut Fur Pharmazie Und Lebensmittelchemie Julius-maximilians Universitat

• Peer Markus

  Julius-von-sachs-institut Julius-maximilians Universitat

• Warzecha Heribert

  Technische Universitaet Darmstadt Department For Biology

• Frank Andreas

  Institut Fur Pharmazie Und Lebensmittelchemie Julius-maximilians Universitat

関連論文

• Bioconversion of the antihistaminc drug loratadine by tobacco cell suspension cultures expressing human cytochrome P450 3A4(PLANT BIOTECHNOLOGY)

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