女性における血管内皮機能と凝固線溶系に及ぼす加齢および脂質要因の影響
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概要
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Female physiological characteritics of the vascular endothelial cell function and coagulationfibrinolysis system were investigated in terms of the effect of aging, lipid metabolism and ovarian function. The plasma levels of thrombomodulin (TM) and tissue-type plasminogen activator (tPA) were correlated with age. The plasma level of tPA was correlated with the atherogenic index (AI). The menopausal group had higher plasma levels of TM, tPA and antithrombin III than the groups having menstruation. The mean flection point of the cubic expressions between the age and the endothelial cell substances or coagulation-fibrinolysis factors was 48.0 years of age which was the same as the age for the climacterium. The percent increase in the plasma level of tPA determined by a venous occlusion test had a negative correlation with AI. The percent increases in tPA and 6-ketoprostaglandin F_<1α> tended to differ between the group whose menstruation was regular and the group in which it was irregular. Multivariate analysis showed a significant multiple correlation of age with tPA, AI and plasminogen activator inhibitor and a significant canonical correlation of the endothelial cell substances with coagulation-fibrinolysis factors. These findings suggest that the vascular endothelial cell damage progressed with aging and lipid levels and was positive in the menopausal group. They also suggest that aging, lipid metabolism and ovarian function are involved in the endothelial cell function and coagulation-fibrinolysis system in females.
- 東京女子医科大学の論文
- 1996-03-25
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