糖尿病と脂質代謝異常(<シリーズ>「糖尿病の治療」(12))

概要

論文の詳細を見る
Diabetic patients frequently show lipid abnormalities that include not only quantitative but also qualitative changes in lipid profile leading to the occurrence of atherogenic lipoprotein particles. Given the greatly increased risk of coronary heart disease (CHD) in diabetic patients with hyperlipidemia, most principal clinical guidelines for the care and treatment of diabetic patients recommend aggressively lowering lipid levels in such patients. In fact, several large-scale clinical intervention trials have successfully shown that lipid-lowering agents, particularly statins, could significantly reduced the CHD risk in diabetic patients with hyperlipidemia. Such patients should initially adjust their own life style, especially focusing on appropriate diet and exercise, and thereafter receive drug-therapy, if necessary. According to the result of our investigation on 10,000 Japanese diabetic patients, about a half of the total patients had hyperlipidemia and only less than half of the hyperlipidemic patients received some lipid-lowering agents. Taken altogether, it should be concluded that more stringent and aggressive intervention will be recommended in the treatment of Japanese diabetic patients with hyperlipidemia.