Adsorption of Antibody Protein onto Plasma-Polymerized Film Characterized by Atomic Force Microscopy and Quartz Crystal Microbalance(Organic Molecular Electronics)

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概要

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• Adsorption of antibody protein (anti-human IgG) onto plasma-polymerized thin films (PPF) with nanoscale thickness was characterized by atomic force microscopy (AFM) and quartz crystal microbalance (QCM). The PPF surface is very flat (less than 1nm roughness) and its properties (charge and wettability) can be easily changed while retaining the backbone structure. We focus on two types of surfaces: one is the pristine surface of hexamethyldisiloxane (HMDS) PPF (hydrophobic) and the other is an HMDS PPF surface with nitrogen-plasma treatment (hydrophilic and positive-charged surface). The AFM image showed that the antibody molecules were densely adsorbed onto both surfaces and individual antibody molecules could be observed. The QCM profiles show a corresponding tendency with the AFM images. These results indicate that the plasma polymerized film can be the suitable biointerface for the application of biosensor and bioassay.

• 社団法人電子情報通信学会の論文
• 2007-03-01

著者

• MIURA Satoshi

  Graduate School of Science, Tohoku University

• Murata Naoya

  Shibaura Inst. Of Technol. Tokyo Jpn

• Muguruma Hitoshi

  Shibaura Inst. Of Technol. Tokyo Jpn

• Muguruma Hitoshi

  Graduate School Of Electrical Engineering And Department Of Electronic Engineering Shibaura Institut

• MURATA Naoya

  Graduate School of Electrical Engineering and Department of Electronic Engineering, Shibaura Institu

• Miura Satoshi

  Graduate School Of Electrical Engineering And Department Of Electronic Engineering Shibaura Institut

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