EFFECTS ON MICE OF LONG-TERM EXPOSURE TO ORGANIC SOLVENTS IN ADHESIVES

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概要

• 論文の詳細を見る

• To determine the ingredients as organic solvents and their amountsm four adhesives currently available on the market were analyzed. The relationship of concentrations of the organic solvents between air in the exposure chamber and blood of the mice exposed to adhesives was also evaluated. The effects on mice of long-term exposure to adhesives were further experimentally investigated. Four kind of adhesive (A, B, C, D), which contained several different ingredients of organic solvents, were used for the experiments; organic solvents accounted for 52.6-69.7 percent of the total adhesives. The adhesive C which mainly contained acetone, ester and alcohol, and the adhesive D which contained mostly acetone, ester and hydrocarbon were used for the mouse exposure test. Increase in the concentration of organic solvents in the exposure chamber was found to be well parallel to the increase in the amount of adhesives C and D used. Oxygen concentration in the exposure chamber was at least 18 percent during the exposure. Blood content of the organic solvents in the exposed mice was similar to that in the exposure chamber for adhesive C, but different for adhesive D. This finding was seemingly attributable to the similarity and the difference in the uptake and metabolism of the organic solvents in mice. Depending upon the kind of adhesives, different patterns of disappearance of organic components from blood were observed. Ethyl alchol could be no longer detected in blood in 30 min after exposure, so did cyclohexane in 3 h, whereas acetone could still be detected in 12 h after exposure. All organic components could be no longer detected in blood in 24 h after exposure. Mice exposed to adhesive C for a long period showed the increase in food and water intake, decrease in white blood cell count, and greater liver/ and kidney/body weight ratios. Those exposed to adhesive D demonstrated the inhibition of body weight gain, decrease in food and water intake, suppressed locomotor function, decrease in white blood cell count and greater liver/body weight ratio. These results indicate that long-term exposure to the organic solvents in adhesives may cause not only somatic but also functional failures in the animals. From similar considerations to humans much attention should be paid for daily lives so as to avoid the continuous use of adhesives in an enclosed workplace, taking extra care to ensure proper ventilation.

• 名古屋市立大学の論文
• 1984-03-26

著者

• 成瀬 正春

  Department of Hygiene, Nagoya City University Medical School

• 成瀬 正春

  Department Of Hygiene Nagoya City University Medical School

関連論文

• ON USE OF GLOVES IN THE HOME AND THEIR INFLUENCE UPON SKIN IRRITATION
• EFFECTS ON MICE OF LONG-TERM EXPOSURE TO ORGANIC SOLVENTS IN ADHESIVES

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