肝星細胞研究(特別講演IV, 第59回名古屋市立大学医学会総会)

概要

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Hepatic stellate cells constitute the sinusoidal wall as liver specific pericytes and store vitamin A-associated lipid droplets. In liver injury, hepatic stellate cells undergo activation proliferation and migration and generate a large amount of extracellular matrix materials. Stellate cells activation is an important event in pathology of liver diseases because it is believed to play roles in the development of fibrosis. The analysis of genes associated with stellate cells activation could provide a clue to the molecular mechanism and gene therapy of fibrotic liver disease. Although the molecules characteristic of activated hepatic stellate cells have been extensively studied over a decade, here we introduce the date from the suppressive subtraction hybridization, the homology PCR of receptor tyrosine kinase, microRNA array analysis we employed.
2009-10-01