The Interaction of Oxaliplatin(Pt(oxalate)(1R, 2R-cyclohexanediamine)) with DNA Visualized by an Atomic Force Microscope

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概要

• 論文の詳細を見る

• The structural changes of DNA caused by PtCl_2(diaminocyclohexane (DACH)) were observed by an atomic force microscope (AFM). The AFM image of pUC19 DNA treated by Eco RI show that the DNA is shaped like a string. The AFM image of DNA treated with PtCl_2(DACH) at a ratio of platinum compound / base pair (r)=1.0 or 0.1 is very different from that of DNA and shows an ellipsoidal sphere in which the string of DNA was rolled up. The DNA treated with PtCl_2(DACH) at the ratio of platinum compound / base pair (r)=0.01 is also shaped into a ball, but the diameter of the ball is larger than that treated with PtCl_2(DACH) at the ratio of platinum compound / base pair (r)=1 or 0.1. It is known that, when the platinum complex binds to the double helix of DNA, a kink occurs in the DNA. The dramatic changes of the shape of the DNA from a string to a sphere were occurred by accumulating the DNA kink induced by the platinum complex.

• 福山大学の論文

著者

• CHIKUMA Masahiko

  Osaka University of Pharmaceutical Sciences

• Hirose Junzo

  福山大学

• Noji Masahide

  Graduate School Of Health Science Suzuka University Of Medical Science

• SATO Takaji

  Osaka University of Pharmaceutical Sciences

• HIKASA Hiroyuki

  福山大学

• SATO Takushi

  Osaka University of Pharmaceutical Sciences

• KIDANI Yoshinori

  Faculty of Pharmaceutical Sciences, Nagoya City University

• Kidani Yoshinori

  Faculty Of Pharmaceutical Sciences Nagoya City University

• Chikuma Masahiko

  Osaka College of Pharmacy

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