Lecithin Cholesterol Acyltransferase および High Density Lipoprotein-cholesterolの臨床的意義

概要

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Lecithin cholesterol acyltransferase (LCAT) and high density lipoprotein (HDL) are synthesized in the liver and released into the circulation. After the esterification of free cholesterol, LCAT is taken up by the liver with HDL and metabolized there. In this study the clinical significance of LCAT and HDL-cholesterol in liver diseases was investigated. Total and free cholesterol, HDL-cholesterol, Cholinesterase and LCAT were measured in 118 patients with liver diseases and 80 normal subjects. The conclusion was summarized as follow : 1) In patients with acute hepatitis, liver cirrhosis and hepatoma, HDL-cholesterol level and LCAT activity were lower than each control value, respectively. 2) There was positive correlation between LCAT activity and cholinesterase level in patients with liver cirrhosis. 3) There was negative correlation between LCAT and free cholesterol level in patients with liver cirrhosis. 4) LCAT activity decreased in acute phase of acute hepatitis, but recovered gradually to normal value. Thus, an investigation on the serum LCAT activity, HDL-cholesterol level and their combination with other parameters appeared to be applicable in estimating the stage and severity of liver diseases.
神戸大学の論文