境界域高血圧症における情動刺激と交感神経活動

概要

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This study was designed to clarify the role of sympathetic nerve activIty playing in the elevation of blood pressure due to the emotional stress in patients with borderline hypertension (BHT). The changes in blood pressure, heart rate, plasma catecholamine (CA) concentration and plasma cortisol concentration were observed before and during mirror drawing test (MDT) in normotensive (NT) and BHT subjects. Furthermore, the effects of clotiazepam (CTP) on these changes were examined. On MDT, the responses of blood pressure and plasma CA concentration were significantly greater in BHT than in NT. Either systolic or diastolic pressure indicated a linear relation to plasma CA concentration in both groups. Following CTP administration, the responses of the blood pressure and plasma CA concentration induced by MDT were significantly supressed in BHT, though no remarkable change was found in NT. In both groups, however, no MDT-induced change in plasma cortisol concentration was found regardless of the administration of CTP. These results indicate that enhanced pressor response to emotional stress in BHT closely relates to an increase in sympathetic nerve activity, and that corticosteroid may play a role in the pressor mechanism through the permissive effect to catecholamine.
神戸大学の論文