慢性下顎骨骨髄炎の基礎的臨床的研究
スポンサーリンク
概要
- 論文の詳細を見る
Production of experimental mandibular osteomyelitis, clinical presentation of 9 cases of mandibular osteomyelitis, studies on the concentration of antimicrobial agents in the mandibular bone marrow, and results of quantitative analysis of alkaline phosphatase activity in the mandibular bone marrow of patients with mandibular osteomyelitis are presented. 1. New Zealand white rabbits infected most effectively by injection of sodium morrhuate and 10^8 colony-forming units of Str. pyogenes S-8 into the marrow cavity of the mandible. 2. Clinical, radiographic, and histo-pathologic findings were given for 9 cases of chronic mandibular osteomyelitis. The results were separated into 2 types. One type involved clear sequestral formation ; the other, non-sequestral formation. The former did not appear to recur after sequestrectomy, whereas the latter appeared frequently after the operation. Concerning histo-pathogenic findings, the former type had bone necrosis and the presence of bacterial mass and neutrophilic leukocytes. On the other hand, the latter displayed degeneration and necrosis of bone with healing lesions in the same bone. 3. Concentration of antimicrobial agents in dog and rabbit mandibular bone marrow: Piperacillin, Cefazolin, and Cefoperazone in the mandibular bone marrow reached 10-30% of serum levels. Lincomycin showed 30% ; Dibekacin, about 10%; and Minocycline, 1%. 4. Concentration of antimicrobial agents in human mandibular bone marrow : Ratio of tissue level/serum level were 0.10-0.19 for Piperacillin, 0.28 for Cefazolin, 0.06-0.10 for Cefoperazone, and 0.09-2.23 for Lincomycin. In the sequestral bone, the values were 0.11 for Cefazolin, 0.05-0.29 for Cefoperazone, and 0.06 for Lincomycin. 5. Alkaline phosphatase activity in the sequestral bone of 10 patients with chronic mandibular osteomyelitis cases was investigated. The enzyme activity was undetectable in the case of clear sequestral formation and 18.39 u/g for the severe non-healing type. Alkaline phosphatase activity in chronic mandibular osteomyelitis was shown to vary, depending on the degree of osteolith formation; it was high in the case of welldeveloped osteolith, and low in the case of clear sequestral formation.
- 神戸大学の論文
著者
関連論文
- 下顎骨への注射用β-ラクタム薬の移行性に関する検討
- 慢性下顎骨骨髄炎における外科的療法施行例の検討 : X線所見と患者背景, 治療成績について
- 口腔蜂窩織炎の臨床的検討 : 第二報 : 治療内容と治療期間の関係について
- 抜歯後感染に関する臨床的検討
- Ofloxacinの抜歯創移行性について-抜歯後の感染予防の検討-
- びまん性硬化性下顎骨骨髄炎に対するマクロライド長期治療に関する臨床的研究 : Roxithromycin 投与での長期観察例について
- 顎顔面領域の感染症成立に影響する全身的要因の研究 : 白血球減少ラットカラゲニン膿瘍モデルを用いて
- 実験的骨髄炎における Roxithromycin のサイトカイン(IL-6, IL-1β)に対する抑制効果
- Piperacillinでの投与量と血清および炎症組織内濃度の関連性
- 慢性下顎骨骨髄炎の基礎的臨床的研究
- 歯科口腔外科領域における非ステロイド性鎮痛消炎剤16091R.P.(メチアジン酸)の臨床使用成績