アイソトープによる脳腫瘍の診断 : 主として^<113m>In-Fe EDTAとシンチカメラによる質的診断について
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概要
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Though the brain scan has been mainly used for the tumor localization, any intraccranial lesions including the non neoplastic ones which destroy the blood-brain barrier could also be demonstrated. Serial scintigraphy was attempted to obtain the information on the time dependecy of the image density of lesions, that would make it possible to qualitatively discriminate each intracranial lesion. The scintillation camera has made such a serial scintigraphy possible with the short intervals in minutes. ^<113m>In-FeEDTA intrduced by Stern et al. 1966 is employed as a suitable agent in this series after the several basic experiments such as the distribution in rabbits, the disappearance from the human blood, and so on. Scintigraphy by the rectilinear scanner were also performed, and the rate ofacuracy in localizing the brain tumor of scintiscans is compared with that of scintiphotos. Subjects and methods : Sixty-one patients all histologically verified by the surgery or autopsy including 12 non neoplastic cases were investigated. ^<113m>In-FeEDTA was prepared by the method of Stern et al. after eluting ^<113m>In from the ^<113>Sn-^<113m>In generator with 0.04N HGl. Scintigraphy by the rectilinear scanner with 3"Φ×2" NaI crystal crystal and 37-hole focusing collimator was performed 30 minutes after the administration of ^<113m>In-FeEDTA in 100〜200μCi per Kg of body weight. Frontal, or occipital, and bilateral views were recorded in scintiscans. Scintigraphy by the scintillation camera, equipped with 1000-hole parallel collimator, was performed immediately after the administration of the same dose. Because of the little time in recording, the frontal, occipital, bilateral views, and if necessary, the vertex, frontovertex and suboccipital views were sequentially recorded not fail to delineate and and still more to qualitatively diagnose the lesion. Results : 1) the rate of accuracy in localizing the brain tumors of scintiscans is 88% (14/16) that is equal to that of scintiphotos (29/33). The resolution of images of scintianscs and of scintiphotos is almost the same. 2) Positive scintigrams in 12 non neoplastic lesions were 10 (83%). 3) Serial scintigraphy of each lesion produced individually characteristic pattern that suggests the possibility of qualitative evaluation of the intracranial lesions. The up-take of the radioactivity in the tumor increases with time until its peak comes during 30 to 60 minutes. The more the tumor malignant, the higher the up-take and the earlier the time to reach its peak. The lesions of hypervascularity has the best delineation in earlier scans, and the up-take of radioactivity decreases with time. Edema in the surrounding tissue is will defined abut 20 minutes after the administration of the agent.
- 千葉大学の論文
著者
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