二次抗結核剤の抗菌力に関する実験的ならびに臨床的研究

概要

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The effects of the secondary tuberculostatics were investigated from the stand points of the minimum inhibitory concentrations of the drugs against intra and extracellular tubercle bacilli the results of combination with the other drugs and the relationship between specific serum antimycobacterial activities of the drugs and the therapeutic efficacies in the treated patients. Ethionamide, Cycloserine and Ethanbutol as well as Isoniazide were much more effective against the tubercle bacilli (Strain H_<37> Rv) situated within mononuclear leukocytes of guinea pigs than Kanamycin, Capreomycin as well as Streptomycin, comparing with their efficacies against the extracellular bacilli. Ethionamide, Cycloserine and Ethanbutol attainable relatively low blood levels in human being were enhanced their antimycobacterial activities by the combinations with the other drugs. In the N_<IIa> type by Gakken's classification of not easy curable pulmonary tuberculosis, the best responses were brought to the cases that had high specific serum antimycobacterial activities induced by the, at least, two unused secondary antituberclotics. On the other hand, in the group of patients having more advanced pulmonary lesions, N_<III> type, the activities did not indicated preconception of the therapeutic efficacy.
千葉大学の論文