子宮頸癌発生実験における異型増殖性ならびに癌性実質組織の^3H-thymidine反応とその基質の変化との関係について
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^3H-thymidine autoradiographic studies were performed on stromal changes of 20-Methylcholanthrene-induced cervical cancer in mice in order to clarify some characteristic differences between malignant and benign cervical lesions. Of 115 experimental cases of the uterine cervix, 35 revealed invasive cancer including 2 cases with metastasis in the lumbar lymph nodes, 18 atypical hyperplasia including 6 cases with atypia of high degree and 62 non-atypical hyperplasia of the cervix. 40 controlled cases showed normal squamous epithelia. The observations obtained are as following. 1) The number of ^3H-thymidine uptaking cells in the epithelial proliferation seems to increase in accordance with the grade of atypia. 2) In cervical cancer, all the mesenchymal cells of the stroma closely adjacent to the labelled parenchymal cells, were found unlabelled with degneration and nekrosis of mesenchymal cells. Labelled mesenchymal cells, however, were found in the stroma apart from the labelled parenchymal cells of carcinoma. 3) In normal squamous epithelia and hyperplasia with non- and slight atypia, labelled mesenchymal cells were observed both closely adjacent to and apart from the labelled epithelial cells. 4) In hyperplasia with severe atypia, what we called precancerous changes, unlabelled mesenchymal cells with nuclear degneration were partially encountered adjacent to labelled parenchymal cells. Accordingly all above mentioned findings support the theory that parenchymal proliferation of malignant tumors causes Mesenchymodystrophy and Mesenchymolysis (Takizawa).
- 千葉大学の論文
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- 子宮頸癌発生実験における異型増殖性ならびに癌性実質組織の^3H-thymidine反応とその基質の変化との関係について