リウマチ因子に関する研究

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It has long been one of the most important problems in the practice of medicine to solve a riddle of rheumatoid factor, an agglutinating activating factor. This paper is a serological approach to rheumatoid factor. Although several serological reactions have been widely performed in differentiating rheumatoid arthritis been widely performed in differentiating rheumatoid arthritis from the similar disease and the specificity of serological reactions is still in dispute, comparative studies of these serological reactions and mutral relations between these reactions and the forms of rheumatoid arthritis are not yet enough and clearly discussed. Comparison of three serological reactions (RA-test, Waaler-Rose Reaction, modified Waaler-Rose Reaction) and paper electrophoresis, and immunoelectrophoresis were simultaneously performed as to approximately 250 cases of sera obtained from the patients of rheumatoid arthritis and similar disease. The results were summarized as follows : 1) Three serological reactions showed various strength-degree of agglutination, regardless of the form and symptom of rheumatoid arthritis, classified according to the diagnostic criteria of the American Rheumatoid Association. This fact suggested that rheumatoid factor would be made up of multiple components. 2) Inhibition tests of three serological reactions demonstrated non-significant inclination notwithstanding the nature of α-globulin (7S α-globulin or 19S α-globulin), but the difference in activating strength of rheumatoid factor was observed in each serum. 3) Paper electrophoresis of the patients' sera showed an increase in a_1-and α_2-globulin levels, and corresponding to this increase, characteristic precipitation lines, β_2M and α_2M, were observed in immunoelectrophoresis.
千葉大学の論文

リウマチ因子に関する研究

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