精神分裂病の脳波学的研究 : 特に薬物治療経過と脳波変化について

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概要

• 論文の詳細を見る

• Serial electroencephalograms were studied in 63 schizophrenics under chlorpromazine and/or levomepromazine therapy. The pretherapy EEGs and the follow up ones were compared in terms of drug-induced changes. The EEG features of the drug-induced changes were of four types. Type 1. Slowing of the background activity with paroxysmal changes. Type 2. Paroxysmal activity. Type 3. Slowing of the background activity only. Type 4. No change (the background activity and paroxysmal activity). The four types of EEG changes were set against various clinical features. 1. Somewhat higher correlation was found between the paroxysmal type of EEG change and the patient's history of head injury. 2. Doses of the drugs were not correlated with the EEG changes. 3. The types of the drug-induced EEG changes were not correlated with psychic events, such as readaptation in the hospital life, improvement of rapport and appearance of partial insight (Krankheitsgefuhl) as the landmarks of clinical improvement. 4. EEG variability in the course of drug therapy should be taken into consideration. Patients were divided into two groups : Group 1. Variable : new occurrence of EEG changes in the frames of slowing of the background and/or appearance of paroxysmal activity. Group 2. Unchanged : no newly occurred change in EEGs. Clinical improvement was exceedingly high in the variable group, especially in those with additional paroxysmal activity. 5. Classical three disease types (hebephrenic, catatonic and paranoic) were not correlated with EEG changes ; while clinical courses, typical or atypical, were more intimately related with EEG variability. There was high correlation between the atypical course and the variable group, especially those with additional paroxysmal change. Clinical remission was high in the atypical schizophrenics. It was thus suggested that changes of the background activity and those of paroxysmal activity may be of different natures.

• 千葉大学の論文
• 1967-03-28

著者

• 小野 幸雄

  千大神経科

• 小野 幸雄

  千葉大学大学院医学研究科内科系神経精神医学

関連論文

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• 精神分裂病の脳波学的研究 : 特に薬物治療経過と脳波変化について
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