筋生検による進行性筋ジストロフィー症の組織学的研究 : 特に神経終末を中心として(<特集>脳と神経の研究II)

概要

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1. The histological changes observed in muscle biopsy specimens removed from 12 cases of muscular dystrophy, including 11 cases of Duchenne-type and 1 of the limb-girdle type, were studied. 2. The abnormalities recognized in sections stained with haematoxylin and eosin were described. 3. The intramuscular nerve fibers and endings were selectively stained by intravital methylene blue, the synaptic region of the motor end plates demonstrated by a modification of the thiocholine method of Koelle, and the results were tabulated and described. 4. The findings in these cases indicated that muscle fiber necrosis and proliferation of interstitial fatty and collagen tissues were common and that evidence of spontaneous regeneration was not infrequent. 5. The various types of nerve fiber, end plate and synaptic region changes were seen in all of the cases. 6. This study revealed various abnormalities of intramuscular nerve fibers and motor nerve endings, some of them similar to those seen in neurogenic muscle disease and in polymyositis, but sensory nerve endings of muscle spindles and sensory nerve fibers were well preserved even though the muscle fibers had reached an advanced stage of degeneration.
千葉大学の論文
1965-11-28