副腎皮質ホルモンによる下熱機構

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概要

• 論文の詳細を見る

• It was shown that there are marked differences in the febrile and the leucocytic responses, to endotoxin in dogs and rabbits. The leucocytic response in dogs seemed mainly to result from the mere trapping and the later release of leucocytes, and the role played by the endogenous leucocytosis-inducing factor demonstrated in rabbits was only a minor one. The endogenous pyrogen observable in dogs had no correlation to the leucopenic response as in the case of rabbits. Instead its appearance seemed to be associated with the endotoxin intoxication which casually related to hepatic responses after taking up endotoxin in hepatic reticuloendothelial cells. The liberation of the endogenous pyrogen from the liver as a result of hepatic responses could be demonstrated. This hepatic pyrogen was heat-unstable and had no effect upon leucocytes counts. The prevention of the endotoxin fever by glucocorticoids was shown to be the result of suppression of the hepatic metabolic response including the liberation of the hepatic pyrogen.

• 千葉大学の論文
• 1965-05-28

著者

• 村田 和夫

  国立千葉病院整形

• 村田 和夫

  千葉大学大学院医学研究科生理系生理学

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• 副腎皮質ホルモンによる下熱機構

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