感染症shockに対する副腎皮質hormone奏効機序

概要

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It was shown that the extreme susceptibility to endotoxin after adrenalectomy in dogs seems to be due to the intensification of hepatic responses to endotoxin. The complete depletion of liver glycogen and the attendant severe hypoglycemia were easily induced and together with these, an endogenous "shock inducing factor" was found to be liberated from the liver. This factor could be detected by passive transfer. By inducing a hepatosplanchnic blood pooling it seemed to determine severity of the shock. It was non-dializable and heat-unstable. Glucocorticoid could prevent its formation or release but could not inhibit its action. Thus the mechanism of protection of endotoxin shock by glucocorticoid in adrenalectomized dogs was found to be due to the prevention of the onset of the hepatic responses. Once the responses were started, it was hardly possible to check them by glucocorticoids. Eeally the timing of the glucocorticoid administration was of prime importance.
千葉大学の論文
1965-05-28