集団駆虫による二次効果としての蟯虫感染予防の試み

元データ 1965-03-28 千葉大学

概要

A programme for mass treatment as part of measures to control pinworm infestation had been under way from April, 1958 to February, 1963. Our programme, in which pyruvinium pamoate was used, included all the inhabitants of Kawachi community (population about 140), Toei Town, Kitashidara County, Aichi Prefecture. We conducted a study of the secondary effect of deworming in preventing pinworm infection. 1. At the beginning of 1958, the rate of pinworm infestation among the inhabitants was 73.8% for three day annal examination by the scotch tape method. School children had the highest rate, followed by infants and children. The rates found among adults and old persons were relatively high. There was no difference in the rate between men and women. 2. Preliminary deworming was conducted in order to compare its results with the results of method using pyrvinium pamoate. Persons positive for pinworm were stratified according to the density of worm eggs, and were divided into three groups at random. An adult dose of 14gm. of piperazine was given to each group in 3, 5 and 7 day installments respectively. The rates of negative conversion for the three groups were 48.6, 71.4 and 43.2% in the indicated order, the group given with the drug in 5 day installments showing the best results. There was a big difference in the rate of negative conversion between the group of persons positive for annal examination for 5 consecutive days and the group of persons who were not, the rate for the former being 20% and the rate for the rate latter being 70%. The cumulative reinfection rates were high among persons who showed a negative conversion after deworming following 5 day annal examination, the rates being 35% after 2 months, 62% after 4 months and 71% after 8 months. Administration of pyperazine in 5 day installments in 1960 resulted in 65% of negative conversion for worm eggs. The reinfection rates were 26.8% after 2 months and 48.2% after 4 months. 3. Following preliminary deworming, deworming with pyrvinium pamoate had been carried out since February, 1961. The drug was administered to persons under study in doses of 2 to 3mg. per kg. of body weight once a month for consecutive 3 months. The rates of negative conversion for worm eggs for the three groups were 80.8%, 59.1% and 91.6% respectively for 7 day annal examination after 2 weeks. The reinfection rates were 15% after 2 months, 42% after 4 months, 56% after 6 months, and 70% after 1 year. The reinfection rates were lower than in preliminary deworming. On the other hand, the positive rates for different communities varied from 10 to 30%, with the positive rate for 7 day annal examination after 1 year being 50%. This indicates that deworming has a secondary effect of preventing infection. The cumulative positive conversion rates among persons divided by the types of living showed a difference in their courses. One year after deworming, the positive conversion rate among infants, children and school children was nearly 100%, followed by adults and old persons in the indicated order. The rates of heavy infection followed the same pattern, with the rate being highest among school children.

著者

内田 昭夫 千葉大学医学部高次機能制御研究センター、生体情報分野
内田 昭夫 千大・農山村
荒木 武雄 千葉大学医学都農山医学研究施設
近藤 武男 千葉大農研
内田 昭夫 千葉大学医学部農山村医学研究施設
荒木 武雄 千葉大学農山村研究施設
近藤 武男 千葉大学医学部農山村医学研究施設
岡山 虎男 千葉大学医学部農山村医学研究施設
内田 昭夫 千葉大学医学部公衆衞生学教室

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