電気通流によるザリガニ巨大神経線維の膜抵抗変化(<特集>脳と神経の研究)

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Through observation with intracellular microelectrods impaled in crayfish median giant axons, the change in effective resistance of the memberane produced by long-lasting direct current flow could be measured. By application of the anodal direct current, membrane resistance increased gradually with time course of the order of sec. At the same time, it was found from the currentvoltage relation curve, that the rectifying properties of the membrane increased. These effects were also observed in the axons per fused with K-free solution. On the contrary, by application of the cathodal direct current, membrane resistace first decreased markedly because of the rectifying properties of the membrane, and then increased gradually, but, it occured on a level far lower than the initial value before application of the current. At the same time, it was found from the current-voltage relation curve that the rectifying properties of the membrane decreased. The gradual increase in the membrane resistance during the applied cathodal current flow, is due to a decrease of the rectifying properties. The resting membrane resistance itself however, is decreased compared with the value before application of the cathodal current. These effects, i. e. the decrease in the membrane resistance, and that in the rectifying properties, were also observed in axons per fused with K-excess solution. It is concluded then, that the long-lasting direct current results in changes not only in the membrane potential, but also in K-concentration in the space just outside the membrane. Consequently, gradual changes in the membrane resistance are due to these changes in the K-concentration.
千葉大学の論文
1964-09-28

電気通流によるザリガニ巨大神経線維の膜抵抗変化(<特集>脳と神経の研究)

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