ネフローゼ症候群における甲状腺機能の検討

概要

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Recent data have suggested abnormalities of many thyroid function tests in nephrotic syndrome. The thyroid status in 18 patients with nephrotic syndrome was studied on the following subjects ; i) usual thyroid function tests, ii) thyroxine metabolism, iii) thyroxine binding capacity of serum proteins by means of continuous flow electrophpolesis, and iv) thyroidal-^<131>I uptake-TsH test. Conclusions ; 1) Urinary excretion of FBI, dilated thyroxine space and decreased thyroxine binding capacity of TBG and TBPA result in low serum FBI and short biological half time of ^<131>I-thyroxine. 2) High ^<131>I-triiodothyronine erythrocyte uptake is due to deccreased thyroxine binding capacity of serum proteins. 3) Peripheral matabolic disturbance of thyroxine in nephrotic syndrome probably increases TSH secretion in the pipuitary gland, which will result in high thyroidal ^<131>I-uptake. 4) Pipuitary-thyroid axis disturburnce is thought to exist in nephrotic syndrome. 5) Most of the abnormalities in thyroid function tests will correlate with the severity of the disease in their degrees.
千葉大学の論文
1963-03-28