Alimemazine (6549 R. P.)に関する薬理学的研究
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概要
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Alimemazine, DL-10-(3-dimethylamino-2-methyl-propyl) phenothiazine is a new phenothiazine derivative, and has shown antihistarninic and antipruritic qualities in clinical studies, but its tranquillizing effect has not been studied clearly. The experimental investigations on various pharmacological properties of this substance were performed mainly on cardiovascular and central effects. From the present series of experiments, it may be summarized as follows : 1) Alimemazine exerts an inhibitory action on isolated heart and causes vasodilatation of peripheral vessels. 2) In unanesthetized rabbit, the intravenous injection of 1 mg/kg or 5mg/kg of alimemazine causes a fair in blood pressure, and a dose of 1 mg/kg intracarotidly of alimemazin causes a dramatic drop in blood pressure. The intravertebral injection of 0.2-0.3 mg/kg of alimemazine causes a marked fall in blood pressure. 3) Alimemazine decreases the vasopressor response to adrenaline or vasodepressor response to acetylchline, and decreases the contraction of frog's rectus muscle by acetylcholine. 4) Alimemazine reduces the fall or rise in blood pressure caused dy excitation of the peripheral or central end of the cut vagus. 5) Alimemazine decreases the contraction of nictitating membrane of cat, which is produced by excitation of the cervical sympathetic nerve or intravenous injection of adrenaline. 6) Alimemazine exert a sedative action on mouse and rabbit. 7) In conscious unrestrained rabbit, the intravenous injection of 5 mg/kg of alimemazine produces the sleep pattern which is not blocked by acoustic stimuli, but this pattern is not longer than that of chlorpromazine. 8) Alimemazine depresses the monosynaptic reflex discharge in soleus muscle of cat.
- 千葉大学の論文
- 1960-09-28