放射性燐P^<32>の腫瘍集中性並びに子宮癌の診断について
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概要
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Radioactive P was injected into albino rats that had previously been inoculated subcutaneously with a suspension of Yoshida's sarcoma cells, as well as into patients with uterine cancer, to determine whether any significant increase in concentration of the isotope could be demonstrated in malignant tumors and to find out if P^<32> might prove to be a useful tool in the diagnosis of uterine cancer. Radioactivity was determined by Geiger-Muller counter, and radioautography. Uptake of P^<32> by Yoshida's sarcoma cells injected subcutaneously was much lower than that by the bones, nearly the same as that by the spleen and liver, and much higher than that by the blood, skin and brain. Microradioautographs showed dark shadows corresponding in location to the colonies of sarcoma cells in the specimens of fluid in the peritoneum of rats inoculated with Yoshida's sarcoma. Figures of P^<32> counts found in erosion of portio vaginalis and myoma tissue in vivo were nearly the same as figures for uninvolved portions of the same tissues. Assay of specimens of cancer tissue from 40 patients with cervical and corpus cancer showed a markedly higher concentration of the isotope in malignant tissues than in normal tissues. Radioautographs showed markedly dark shadows in malignant tissues. Malignant tissue in endometrium in the secretory phase generally showed a high P^<32> count. This observation appears to suggest a relationship of proliferation and hyperfunction to phosphorus metabolism. Using stripping films and glass tops with sensitized surface, expriments were carried out in vivo to study the method of radioautography in cervical cancer and erosion of portio vaginalis.
- 千葉大学の論文