遷延卵白感作ウサギにおける馬杉腎炎の病理組織学的研究
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The author produced Masugi nephritis in rabbits which had received prolonged sensitization with egg white. Biopsy materials were resected repeatedly from kidneys and their histopathological changes were examined. Four animals of the first 2 groups were sensitized with egg white for sixty days. Two rabbits of group I received single intravenous injection of 1:320 anti-rabbit-kidney duck serum and next 2 rabbits of group II received 1:640 anti-kidney serum. Two animals of group III and three animals of group IV were sensitized with egg white from 110 days to 140 days. The former rabbits were injected intravenously with 1:160 anti-serum and the latter rabbits were injected with 1:640 anti-serum. Masugi nephritis in the sensitized rabbits in each group which showed a remarkable decrease of albumin fraction and increase of total protein and gamma-globulin, namely, a dysproteinemia were relatively stronger and more protracted than that of the control animals. In one case of group II and in two case of group IV fibrinoid degeneration and thrombosis "were detected, while there were no such changes in the control rabbits. It may be worthy of note that one case in group IV demonstrated charactaristic fibrinoid necrotizing glornerulonephritis mit strong plasm exudation.
- 千葉大学の論文
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