栄養失調症に於ける肺の病理形態学的所見

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Pathologic study of sepcimens of the lungs from 31 autopsy cases of dystrophia, not including those of aspiration pneumonia and pulmonary tuberculosis, produced the following result: There were marked congestion and edema in all the specimens examined. Microscopic study of the specimens from the cases in early stages of the disease showed atrophy and edematous thickenning of the walls of the alveoli pulmonum, congestion of the capillaries, perivascular infiltration of the round cells, edema, deposition of fibrin, diapedesis of leukocytes and erythrocytes in the alveoli pulmonum, and proliferation of the desquamative epithelial cells. These pathologic changes, which suggest the presence of circulatory disorder or the so-called serous inflammation, closely resemble the pathologic changes that are observed in uremic pneumonia. This indicates that toxemia may have been present in these cases. The alveolar sac, when its insusceptibility to noxious agents is lowered by prodromal changes like the ones described above, is liable to provide an ideal condition for multiplication of micro-organisms, developing alveolitis eventually. Many specimens under, study showed evidence of pneumonia. A lowered vital resistance was also in evidence in these specimens, where there was a tendency to necrosis and progressive inflammation of the lung tissue, with marked perifocal inflammation. Pathologic changes in the bronchi were more moderate than those in the alveoli, supporting a view that in these cases alveolitis might first occur, and pneumonia supervene, with changes in the alveoli taking place earlier than those in the bronchi.Professor Takizawa, based on the result of experiments on the effects of low caloric diet, low animal protein diet and fasting in dogs, as well as of pathologic study of various organs from cases of dystrophia, postulated that, "besides atrophy of the tissue caused by defective nutrition, toxemia due to metabolic disturbance and circulatory disorder or the so-called serous inflammation, which is caused by toxemia, are the chief pathologic manifestations of dystrophia." The result of pathologic study, made by the author in the lung specimens from case of dystrophia, confirmed the presence of circulatory disorder or the so-called serous inflammation, i. e. metabolic toxemia. It is supposed that these prodromal changes in the alveoli in dystrophia may lead to a lowered vital resistance, causing first alveolitis and then "lobular pneumonia" to develop.
千葉大学の論文

栄養失調症に於ける肺の病理形態学的所見

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