肝吸虫症の治療に関する研究 : 特に燐酸クロロキン治療に関して
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Forty-one patients with clonorchiasis and persons infected with the eggs of Clonorchis were treated with chlorquinine diphosphate alone, with good results. Chlorquinine diphosphate was orally given in a daily dose of 500mg. Examinations performed after treatment showed that the eggs in duodenal secretions either disappeared or decreased in number in 27 out of 30 cases (90 per cent). It was after the drug had been given 33 days on the average that the eggs wholly disappeared. The stools of 13 cases, in which the eggs had been detected prior to treatment, became free of eggs after 13 days of treatment on the average. Examinations of 8 cases performed twice following the initial disappearance of eggs in duodenal secretions showed that there were on eggs at all in 4 cases, smaller number of eggs than before treatment in 2 cases, as many eggs as before treatment in 1 case and a larger number of eggs than before treatment in 1 case. Subjective symptoms disappeared concomitant with a decrease in number or disappearance of eggs, and there was evidence of an improvement in liver function in cases with disturbed liver function. Examinations of the blood samples obtained from the ear lobe showed that there was an improvement in eosinophil cell count, though treatment had no effect on anemia. The treatment was not without its side-effects : many patients complained of dizziness, and some had vomiting and loss of appetite, but- these symptoms were not so severe as to require any remedy. In view of the results described above, it would seem that chlorquinine diphosphate is more effective on clonorchiasis than antimonies.
- 千葉大学の論文
- 1958-11-28
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- 肝吸虫症の治療に関する研究 : 特に燐酸クロロキン治療に関して