ブドウ球菌の薬剤耐性に関する臨床的研究
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概要
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Biological properties of 285 strains of Staphylococcus which had been isolated during the period from June, 1956 to September, 1957 were investigated, and studies were performed on the sensitivity to various kinds of drugs of 174 strains which had given positive reactions to the tests for coagulase. (1) The microorganisms of Staphylococcus aureus which are capable of producing coaglase, decomposing mannitol, causing hemolysis and liquefying gelatin in addition to producing a yellow pigment, accounted for the majority of all the varieties of Staphylococcus isolated from lesions in patients. (2) Of all the strains of Staphylococcus isolated in 1956 and 1957, more than half were resistant to penicillin, and many were resistant to streptomycin, while comparatively few were resistant to chloramphenicol and erythromycin. (3) Of all the strains which had given positive reactions to the tests for coagulase, 55.3 % were resistant to pencillin higher in concentration than 1 μ/cc, 34,5 % to streptomycin higher in concentration than 10γ/cc, 7.4 % to chloramphenicol higher in concentration than lOγ/cc, 23.6 % to tetracyclin higher in concentration than 10 γ/cc, 4.0% to erythromycin higher in concentration than 10 γ/cc, and 9.2 % to sulfisoxazole higher in concentration than 30 mg/dl. The strains resistant to penicillin were most numerous, followed by those resistant to streptomycin and those resistant to tetracyclin in the indicated order. (4) A considerably large number of strains were resistant to 2 or 3 kinds of drugs, and some were resistant to as many as 4 or 5 kinds. The fact that there exist those strains which are aresistant to so many drugs may merit attention from the clinical viewpoint. (5) The strains of Staphylococcus that had acquired resistance to various kinds of drugs have shown a tendency to increase in number year by year. Inadequate use of antibiotics only adds to the increase in number of those strains that are resistant to antibiotics of higher concentrations and a greater number of antibiatis. In the treatment of cases of infection by the strains of Staphylococcus, it is necessary that sensitivity to antibiotics of the strains isolated from patients should be determined, so that the most effective antimicrobial therapy may be administered.
- 千葉大学の論文
- 1958-11-28