無菌飼育動物血清の殺菌力に関する研究
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By raising chicks and guinea pigs in germ-free environment, studies were made chiefly of the germicidal power of the serum obtained from these animals. Their physical development, as well as the influence of the administration of Escherichia coli on it, was also examined. The results are summarized as follows : (1) An increase in weight was more rapid in chicks to which E. coli had been administered after having been hatched in germ-free environment than in germ-free chicks. The former also showed better growth, including the development of the cockscomb, than the latter. (2) Guinea pigs suckled by their mothers showed far better physical development"and more rapid increase in weight than guinea pigs fed on an autoclaved diet and guinea pigs born and raised in germ-free environment. There was small variation in physical development and an increase in weight between the latter two groups. Administration of E. coli caused a decrease in weight in both of these two groups. Its effect appeared to be greater in germ-free guinea pigs, for they were delayed in regaining lost weight. (3) The serum obtained from normal chicks and guinea pigs had a markedly high germicidal power against Salmonella typhi 0-901 ; the serum obtained from guinea pigs was more powerful than the serum obtained from chicks. (4) The serum obtained from germ-free chicks and guinea pigs was far less powerful against S. typhi 0-901 than the serum obtained from normal chicks and guinea pigs. (5) Administration of E. coli to germ-free chicks and guinea pigs caused a marked increase in the germicidal power of the seium against S. typhi 0-901, the serum becoming more powerful than the serufn obtained from normal chicks and guinea pigs. (6) The serum obtaind from guinea pigs fed on an autoclaved diet had a considerably high germicidal power against S. typhi 0-901, which was incresed by the administration of E. coli. Still, it was less powerful than the serum obtained from normal guinea pigs. (7) The serum obtained from germ-frece chicks was so powerless against E. coli that it appeared to have no germicidal power at all. However, administration of E. coli led to an increase in the germicidal power of the serum to a point where it was as powerful as the serum obtained from normal chicks.
- 千葉大学の論文
- 1958-07-28
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- 無菌飼育動物血清の殺菌力に関する研究