蛋白尿に関する臨牀的研究
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The present studies were made for the purpose of contributing to the elucidation of the mechanism of proteinuria. One hundred and eleven patients with various renal diseases were classified into several types and stages according to their clinical picture as well as the results of renal function tests; and in these patients plasma and urine protein patterns were investigated, and the measurement of the rate of permeability of each protein fraction and the minimum glomerular filtrate protein concentration was made by using the formuli described below. Then, the values obtained were correlated with the types and stages of diseases. minimum glomerular filtrate protein concentration = (urine protein concentration × urine volume per minute)/(GFR) rate of permeability = (Percentage of urine protein fraction)/(percentage of plasma protein fraction) It was revealed that plasma and urine protein patterns were specific to each stage and type of disease, while the minimum glomerular filtrate protein concentration and the rate of permeability of each protein fraction varied with the degree of increased permeability of the glomerular membrane and of deficient tubular reabsorption of protein, the number of nephrone still functioning, and the relationship between these three phenomena. It was indicated that this approach to the study of proteinuria would be of value in elucidating its mechanism, and that the minimum glomerular filtrate concentration and the rate of permeability of each protein fraction represented the degree of impairment of the glomerulus and tubulus and the equilibrium between them.
- 千葉大学の論文
- 1958-05-28
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- 蛋白尿に関する臨牀的研究