慢性麻薬中毒に関する臨床的研究
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概要
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The author found no report in respect of narcotic ejection in the process of curing human addicts of narcotic poisoning. Dr. Y. Sakai succeeded in devising a new cure (I. M.), which is being used to exterminate the morphine habit. On the other hand, the author administered intravenous injections at a concentration of 70 % dextrose solution, and found another method of new treatment. Hence, the author inquired into the quantitative variations of morphine ejection into the urine when the drug habit was removed by venous injection of I. M. or 70 % dextrose solution. As a result, it was found that during the treatment of morphine poisoning the patient, who had been discharging morphine prior to the administration of I. M. (or 70 % dext. solu.) injection, discharged it more; and in many cases, in which there had been no discharge before the treatment, such discharge through the urine commenced after the administration of I. M. injection. Those invalids who ceased to eject morphine through the urine a few days after the beginning of the treatment and whose abstinence symptoms disappeared at the same time were completely cured in a short space of time; whereas those who did not emit morphine during the treatment period began to show marked abstinence symptoms and seemed not to be cured. Again, some patients who were clinically found cured with all abstinence symptoms disappearing still continued to discharge morphine for a long time. On the whole, however, the greater part of abstinence symptoms disappeared in all cases when, after I. M. injection, morphine ceased to bedischarged into the urine. In view of these results, the author concluded that, because accumulated morphine is discharged out of the body through the urine, morphine poisoning is cured.
- 千葉大学の論文