1-Hydrazinophthalazineおよび自律神経節ブロック剤にかんする臨床的ならびに実験的循環分析
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Part 1. Studies upon 1-Hydrazinophthalazine (HPZ) 1. The action mode of HPZ is found milder than that of methoniumcompounds both in decebrated animals and carotid sinus preparates (Eb. Koch). The former displays central, ganglionic and peripheral (adrenolytic) blocking action. 2. While pyribenzamine inhibits the bronchospasm set up with histamine in anesthetized dogs, HPZ counteracts this phenomenon. 3. The chronic medication of HPZ proved effective in nearly 50 % of 35 essential hypertensive cases, fixing standards on the basis of the lowering of the dynamical mean pressure above 10 mmHg. However since the fall in blood pressure is not a sufficient criterion in itself for the choice of an antihypertensive agent, the constituent factors of the blood pressure, for example, output, peripheral and elastic resistance were analyzed according to Wezler's new method. From such a point of view the validity can be especially observed in Keith-Wagener's I or II type in which the occurrence of side effects within averaged therapeutic dosage is relatively rare. 4. Side effects appear not infrequently on the whole; once they break out, the hypotensivity of the drugs is influenced unfavourably. Intramuscular injection of 25 mg of HPZ inhibits no more than partially the side effects. 5. HPZ tends to normalize the hemodynamical values of both systemic and renal circulation in those cases on which total peripheral and renal vascular resistance are increased. There is little virtue in HPZ for the treatment of the arterial hypertension in a sense of so-called "Erfordernishochdruck," judging from the renal hemodynamical point of view. 6. In short the chronic use of relatively small dosis of HPZ may be properly indicated to the hypertensive patients in relatively early stage. Part 2. Studies upon Ganglionic Blockades The action mode of ganglionic blockades (diquaternary dibromide-"p", Pentapyrrolidinium bitartrate-"C_5") was studied experimentally and clinically.1. The striking hypotensive effect of either P. or C_5 was recognized in anesthetized dogs; the chief mechanisms exist in the inhibitory action of the sympathetic vasomotor reflexes without any antiadrenolytic effects. 2. The depressant action of ganglionic blockades found in, fixed and anesthetized dogs is mainly due to the reduction of the peripheral vascular resistance. The heart rates, as a rule, somewhat decrease in its frequency by the administration of ganglionic blockades, whereas the bradycardia due to neosynephrine is converted into rather slight tachycardia. 3. While the constant depression can be gained by the parenteral application of ganglionic blockades in hypertensive patients, it can not be observed so easily by oral medication. Especially the reduction of the diastolic pressure is found considerably difficult no matter how the blockades may be applied. 4. The variation of the circulatory response due to the use of ganglionic blockades depends upon the individual tonic state of the autonomic nervous system. 5. The results of the combined use of ganglionic blockades and HPZ proved better with respect to the hypotensive action than those of the singular ; the increased output is normalized, the augmented peripheral and elastic resistance is controlled.
- 千葉大学の論文