諸種薬剤のHohlweg現象に及ぼす影響に就いて
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概要
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What is termed Hohlweg effect is the mechanism in which a stimulus applied to the diencephalon (hypothalamus) by the hormone folliculin causes secretion of F.S.H. and L.H. from the anterior lobe of the pituitary body, resulting in the formation of the corpus luteum in the ovary. As the factors which have influence on this phenomenon also exert influence on the relation between the hormone folliculin and the hormones that stimulate the genital glands, they are of significance from the standpoint of gynecology. For the purpose of investigating into the influence of various agents on Hohlweg effect from this standpoint, the author performed experiments in young female rats, 674 in total, on, how this phenomenon is influenced by the following agents: Methylthiouracil which is said to cause hypothyroidism, Thyradin which reinforces thyroid activity, various copper salts which are believed effective in inducing the discharge of ova, some sympathetic and parasympathetic agents and vitamin C. The results are summarized as follows: (1) The experiments in which the hormone folliculin administered to rats was reduced to 100-50 I.U. so that the corpus luteum positive rate would be lowered, has revealed that this phenomenon is accelerated in hypothyroidism, which it is restrained in hyperthyroidism. (2) Though intravenous injections of copper salts did not cause formation of the corpus luteum in young rats, they, like vitamin C, demonstated an action similar to that of F.S.H. It may be said that they accelerates this phenomenon in so far as they have brought about an increase in the number of the corpus luteum formed in the ovary. (3) The fact that this phenomenon was markedly restrained and accelerated by parasympathetic blocking agents and stimulating agents, respectively, would indicate that the parasympathetic plays an important role in genital function. (4) On the ovary of young rats, vitamin C had the same action as F.S.H. It reinforced the action of the hormone folliculi in so far as it has caused hemorrhagic reaction of moderate degree.
- 千葉大学の論文
- 1957-03-28
著者
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- 諸種薬剤のHohlweg現象に及ぼす影響に就いて