アノイリナーゼ菌保菌者の臨床的所見並びに同菌に対する腸内菌の拮抗性に就いて
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概要
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A new enzyme which has the strong power to decompose vitamin B_1 has been identified and designated aneurinase. Then, the fact that the presence of aneurinase in human feces was proved has led the researchers to a discovery that the enzyme in question is produced by the aneurinase producing organism. A theory has been advanced that the aneurinase producing organism grows in the intestinal canal and causes deficiency of vitamin B_1, or enterogenous beriberi. The author carried out investigations on the disposition for beriberi, the clinical symptoms of carriers of the aneurinase producing organism and the antagonism between the aneurinase producing organism and various species of intestinal bacterial organisms. The frequency of the occurrence of carriers of the aneurinase producing organism among the patients with the complaint of circulatory or gastrointestinal disorder was first investigated; then those who show clinical symptoms of beriberi among carriers of the aneurinase producing organism were examined for the purpose of investigating into the relation between the presence of aneurinase producing organism in the feces andberiberi; and finally biological and immunoserological properties of the aneurinase producing organism isolated from the feces were studied. At the same time, in vitro experiments on theantagonism between the aneurinase producing organism and various species of intestinal bacterial organisms were carried out. The results are summarized as follows : 1) Out of the total of 685 patients whose feces were examined, 90 patients (13.1 %) were proved to be positive for the aneurinase producing organism. Of the total of 255 patients (selected from among the above 685 patients) diagnosed clinically as suffering from beriberi, 54 patients (21.2 %) were proved to be positive, while of the total of 403 other patients, 36 patients (8.9 %) were proved to be positive. In summer. carriers of the aneurinase producing organism tended to suffer from beriberi. 2) The ratios of the numbers of those who harbor the eggs of various species of parasite worms in the intestines to the total number of carriers of the aneurinase producing organism were as follows: Ascaris, 18.2 %; hookworm, 21.9 %; Trichostrongulus orientalis, 20 %; and more than 2 species of those worms, 37.8 %. 3) The aneurinase producing organism was found in the feces of the patients who complained of constipation more often than in the feces of those with other clinical symptoms.4) No marked relationship was observed between the presence of the aneurinase producing organism in the feces and the disease. However, carriers of the aneurinase producing organism were found in the patients afflicted with constipation, gastrointestinal disorder of high degree and anemic symptoms of moderate degree more often than in the patients suffering from other diseases. It seemed that, in hookworm anemia, the number of carriers of the aneurinase producing organism increased with the worsening of anemic symptoms. 5) No aneurinase producing organism was found in the feces of the patients who had been treated with antibiotics. 6) The aneurinase producing organism isolated from the feces was almost identical with B.M.M. in biological and immunoserological properties. 7) In vitro experiments on the antagonism between the aneurinase producing organism and various species of intestinal bacterial organisms have revealed that Clostridium butyricum and Lactobacillus acidophilus inhibit the aneurinase producing organism, while the enterococcus group and the coli group are inhibited by it. 8) The disposition of carriers of the aneurinase producing organism would be associated with the fact that the aneurinase producing organism was found in the feces of the patients suffering from beriberi, constipation and anemia and of those who harbor parasite worm eggs more often than in the feces of the patients with other complaints. It might be said that carriers of the organism have a disposition for beriberi, for, according to the present experiments, they tended to suffer from beriberi in summer when the factors responsible for causing beriberi contribute their share. It might further be said that the administration of Clostridium butyricum and Lactobacillus acidophilus would have prophylactic or therapeutic effect on the diseases caused by the aneurinase producing organism.
- 千葉大学の論文
- 1956-05-28
著者
関連論文
- 9. 食品・食器類より分離された大腸菌の型別観察(第422回千葉医学会例会 衛生学公衆衛生学教室連合会)
- アノイリナーゼ菌保菌者の臨床的所見並びに同菌に対する腸内菌の拮抗性に就いて
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