諸種薬物の血中Cholinesteraseの活性値に及ぼす副腎及び卵巣剔出の影響
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概要
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As part of the program of the pharmacological study on the chemical systems assumed to be responsible for the activities of the nerves, the author performed investigations on the behavior of cholinesterase in the rat from which either the adrenal glands or the ovaries had been removed as well as on the influences of various drugs on the activity of serum cholinesterase. The results are summarized as followes: (1) It was noted that the sexual cycle and the procedures involted in obtaining blood samples and performing operations have had little influence on serum cholinesterase levels measured by biological assay using rectus muscle of the frog. (2) Taking the effect of the change in the temperature on cholinesterase activity into consideration, the temperature was kept at about 20℃ during the experiments. (3) Prostigmine inhibited the activity of cholinesterase, while atropine increased it. (4) The administration of histamine did not cause shock to the rat, exerting no influence on the activity of cholinesterase. (5) Antihistaminics such as benadryl and pyribenzamine exerted no influence on the activity of cholinesterase. (6) Marked change in the activity of cholinesterase did not result from the administration of central anesthetics such as chloroform, ether, urethane and phenobarbital. (7) The administration of cortisone and ACTH did not have any Influence on the activity of cholinesterase in the normal rat. The consecutive administration of estrogen produced no change in cholinesterase activity. (8) The administration of prostigmine brought about the diminution in the cholinesterase activity even after various anesthetics .had already been administered. But the diminution in the activity was more moderate than that produced when pretreatment was not given. (9) The extirpation of both adrenal glands resulted in the increase in cholinesterase activity, which subsequently was reduced as a result of the administration of cortisone and DOC.(10) The administration of ether did not cause any change in the activity of cholinesterase in the rat from which that adrenal glands had been removed and to which histamine administered. The change caused by the administration of prostigmine was the same as that produced when pre-treatment was not given. (11) The activity of cholinesterase was markedly inhibited by the extirpation of the ovaries. The administration of estrogen exerted no influence on this activity. (12) The inhibitory action of prostigmine on the activity of cholinesterase was slight in the castrated rat. No appreciable inhibitory action was displayed by prostigmine even when the castraetd rat had been pre-treated with atropin or urethane. (13) In view of the inhibitory action of prostigmine that abolishes to some extent the action of anesthetics to lower the activity of cholinesterase, the change in the activity of cholinesterase brought about by the extirpation of the ovaries, and the effect of the administration of cortisone on the activity of cholinesterase in the rat from which the adrenal glands had been removed, it would seem that the ovaries as well as hormone secreted from the cortex of the adrenal glands might be responsible for exerting influence through the nerve center on inhibiting the working of the physiological mechanisms of the production of cholinesterase.
- 千葉大学の論文