人体皮膚組織に関する研究

概要

論文の詳細を見る
I. Changes in the Various Elements of the Skin (Extension Side of the Male Forearm) Caused by Aging: Although researches have been conducted by Newmann, Unna, Dohi Gans, Ejiri and others on the subject of the histological changes which are to be caused in the skin in normal persons by aging, the. mechanism of atrophy of the skin occurring in old ages has not been fully clarified yet. Obtaining specimen samples of the skin from the middle part on the extension side of the forearms of forty human males, with the ages ranging from five to eighty, the author performed exhaustive investigations on this subject. The following are the summary of the results: (1) No marked changes due to the differences in age were observed in the stratum corneum, the stratum granulosum, the stratum mucosum and the stratum germinativum of the epiderms; and infiltration of the cells and (Dilatation) of the capillaries in the corium were also free from changes resulting from aging. Vacuolar degeneration of the cells forming the stratum granulosum was sometimes noted but no association of this phenomenon with aging has been observed. (2) Dilatation of hair follicles and increased pigmentation in the stratum germinativum did not take place until the latter part of the fifties. (3) Vacuolar degeneration of the cells in the stratum rnucosum and the stratum germinativum was observed more or less in the similar degree. While the twenties and thirties represented the lowest degree in the occurrence of vacuolar degeneration, there were no great differences in the degrees manifested by other generations. This will indicate that severity in vacuolar degeneration has nothing to do with aging. II. Changes in the Connective Tissue of the Corium (Extension Side of the Male Forearm) Caused by Aging. Using the specimen samples which had been used in the investigations mentioned above, investigations were performed on the changes in the running directions, density diameter, deformed state and branchy state of the elastic fibers of the connective tissue of the corium resulting from aging as well as on what differences due to aging the elastic fibers and collagenic fibers would manifest in their behavior toward coloring, In an effort to investigate into themechanisim of retrograde degeneration of the skin, poisons (0.1cc of 0.1% HCl and 0.2cc of 0.1% NaOH) were injected intradermally in such a way as would incite the appearance of marked redness and formation of blisters but not the occurrence of necrosis, and the affected parts of the skin were removed forty-eight hours later for examinations. (1) Arrangement of the Elastic Fibers of the Skin (Extension Side of the Forearm). The majority of the elastic fibers of the skin of the extension side of the forearm werefound to run in the back-and-fore direction (E), the right-and-left direction (A) and the back-fore-and-slanting direction (D); and very few of them ran in the vertical direction (B) and the slanting direction (C) (See Diagram 2 and Table 2). While the ratio of A:D:E: was 1:1:1: in the twenties, it was 1:1:3: in ages under ten and over fifty, indicating that in the latter the resistance to forces from the outside world had been weakened. (2) Density of the Elastic Fibers. The total number of the fibers showed a tendency to increase as the skin aged. However it began to be reduced after the thirties had been reached. But, as the thickness of the corium was best developed in adolescence, the density of the fibers was higher in infancy and old ages than in adolescence. The density of the fibers was higher in the upper layer than in the lower layer of the corium. (3) Diameter of the Elastic Fibers. The elastic fibers gradually grew in thickness since in infancy and reached the thickest state in the twenties. While they tended to be slightly reduced in thickness after that period, they became thicker again in advanced ages than in the twenties. An increase in diameter occurring in the twenties would represent over-grown phenomenon as claimed by Kojima. An increase in thickness in advanced ages, however, would be attributed to the swelling caused by degeneration of the fibers in view of the results of coloring tests. The author clarified the mechanism of swelling and ultimate destruction of the elastic fibers by artificially causing them to degenerate by means of experimental injections of poisons (hydrochloric acid and caustic potash). (4) Deformed Fibers. Schmidt and Kojima have claimed that the elastic fibers become the deformed fibers as the result of degeneration. In view of the fact, however, that the deformed fibers were found in the young also and that degeneration occurred only in old ages as was proved by coloring tests, the author cannot agree to this view. (5) Branchy State. There was no relationship between the branchy state of the elastic fibers and aging of the skin. (6) The Elastic Fibers and Collagenic Fibers of the Skin on Extension Side of the Forearm. The change in colorability was observed in only those who were over fifty. As this change was similar to that caused by experimental injections of poisons, it is deduced that it represents degeneration of the fibers. Ejiri has claimed that degeneration of the facial skin occurrs as early as in the twenties. The face which is susceptible to irritations coming from without offers different conditions for experimentation than the middle part on extension side of the forearm. Hence it is quite natural that the results of the author's experiments differ from those of his ones. (7) The fibers of the lower layer of the skin manifested lesser degree of changes than those of the upper layer. As was explained by Dohi and others, this would be due to the fact that the upper layer of the skin is subjected to various kinds of irritations originating in the outside world. (8) Irrespective of the kind of poisons used, the elastic fibers and collagenic fibers behaved in the same manner morphologically and in the coloring tests. (9) In the author's opinion, small granulations are the remainders of the sheaths of elastic fibers. Newmann, Schmidt, Sederholm, Passage, Uuna and Kojima have claimed that the small granulations resulted from degeneration of the elastic fibers. Ejiri has deduced that the big granulations would be the section of the elastic fibers and the small granulations the remainders of the sheaths. The author proved the Ejiri's theory by destroying the elastic fibers experimentally by means of injections of poisons. (10) The author has developed a new method-and named it the Samejima's Method-by which the elastic fibers and the connective tissue can be stained at the same time. III. The Sprouting Periods and Their Local Differences of the. Elastic Fibers of the Human Skin It has generally been asserted that the elastic fibers of the human skin establish themselves in the lower layer of the corium in the four or five month fetal stage. But there are no research on the local differences in the sprouting periods. The author conducted investigations on this subject in the samples obtained from various parts of the skin of twenty-five foetuses (three to ten month old). The results are summarized as follows: (1) The elastic fibers came into being at the elbow and knee in the latter part of the third month. They appeared at the sole in the former half of the fifth month and at the extension side of the forearm in the latter half of the fourth month, while their appearances at the palm-in the latter half of the fifth month-were delayed longer than at any other parts. (2) The elastic fibers in the knee, inguinal region and elbow grew suddenly in density after the former half of the fifth month, in the order as listed above. It seems that it is related to the fetal movements. (3) The elastic fibers at the elbow and knee were arranged in a lozenge pattern. (4) Up to the fifth month of fetal stage, the elastic fibers at the lower layer of the skin were higher in density than those at the upper layer.
千葉大学の論文
1955-09-28

人体皮膚組織に関する研究

スポンサーリンク

概要

著者

関連論文

スポンサーリンク