動物腸内に於ける腸球菌及びB. Sporogenesの生理的意義に関する研究
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概要
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A large amount of research has been carried out for many years and notable achievements have been scored by many bacteriologists since Louis Pasteur on how the presence of intestinal bacteria influences host animals. However, the facts about the ways in which they affect animal life are little-understood. This is because their activities are so complicated and . subtle that the fundamental study entails difficulties. The best method to study physiological functions of intestinal bacteria would be the use of animals whose bodies contain no germs at all; a study of the effects of varieties of intestinal bacteria given alone or in combination on germless animals would doubtless contribute to solving this age-old problem. The author, in collaboration with Sukeyoshi Saito, had succeeded in developing equipments of unique design for germ-free rearing of young chicks. In the present experiments, the author gave orally enterococcus germs that account for the majority of lactic acid bacilli and B. sporogenes germs that are typical of bacterial microorganisms causing putrefaction, alone or in combination, to germ-free chicks in order to investigate their effects on them. Following are the summary of the results of experiments: 1) When germ-free chicks had been given enterococcus germs alone ten days after being hatched, they became vigorous and manifested marked increase in body weight, showing facilitation of growth. A series of investigations of feces has revealed that no other germs than those of enterococcus were found. This will demonstrate that the germs given orally has lodged in the intestine. 2) B. sporogenes germs given orally to germless chicks ten days after being hatched caused diarrhea, despondency and loss of, or cessation of increase in weight starting on the next day. Although normal growth was gradually resumed in about a week, the rate of increase in weight was much worse than that of untreated germ-free animals used as the control.The number of germs found in feces reached the highest level two days after they had been given. Although it showed a decrease since, a uniform number of their colonies has been found persistently. 3) When germ-free chicks had been given a combination of enterococcus and B. sporogenes germs, they manifested normal growth without showing any such noxious effects as diarrhea or a decrease of, or a cessation of increase in body weight. A series of investigations of feces has disclosed that, whereas the humber of B. sporogenes germs reached the highest level two days after they had been given to chicks and tended to be reduced suddenly since, the number of enterococcus germs persistently maintained the high level, demonstrating that the latter antagonized the former in the intestine. 4) The study of intestinal bacteria, whose activities are cmplicated and subtle entails lots of difficulties. However, this problem can be solved if it is attacked analytically, using animals whose bodies contain no germs at all. Advancement in this line of research couldbe greatly accelerated.
- 千葉大学の論文
- 1955-07-28
著者
関連論文
- 6. 干葉市及びその周辺地区の大気汚染の概況(第422回千葉医学会例会 衛生学公衆衛生学教室連合会)
- 家鷄雛の無菌飼育に関する研究
- 動物腸内に於ける腸球菌及びB. Sporogenesの生理的意義に関する研究