血球免疫と唾液免疫における産生抗体の比較
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概要
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Inoue and his colleagues, Tachibana and Sasada, found that group specific agglutinins in immune sera obtained by injection of red blood cells sometimes show that they could not be inhibited by saliva antigens. The fact seems to be of obvious importance but there have been few investigators who have worked on this problem. We have therefore studied this problem in detail and obtained the following results. The group specific antibodies which can act with red blood cell antigens as well as with saliva antigens can be produced by immunization both with red blood cells and with saliva. The antibodies which act with red blood cell antigens but not with saliva antigens can be produced only by immunization with red blood cells, but by no means with saliva. We have now immunized a group of animals with human red blood cells of A, B, and 0 groups, respectively, and the other group with human saliva of the same groups and after the first, third, and the fifth injection as well as after further repeated injections the nature of the developed group antibodies were examined, testing how the formed antibosies were absorbed or inhibited by the saliva antigens of the same group. In the immunization experiments for A, in the serum of rabbits immunized with red blood cells antibodies showed. a difference in nature from those by saliva immunization after the first injection, and after the third injection a part of antibodies was seen which was not absorbed by saliva. Such a part became more manifest after the fifth injection, but remained almost the same after the seventh, tenth and the fifteenth injection. In the case of immunization for B, the development of a part of antibodies nonabsorbable with saliva was seen after the third injection and became manifest after the seventh injection and in some cases more marked after the tenth injection. In the similar experiments in fowl for A the results in the same sense were obtained as in the case of rabbits, but the formation of the antibodies not absorbable with saliva seemed not so significant as in the latter. In the case of immunization for B the formation of antibodies which were hard to absorb with saliva was seen, but not of such antibodies, which could not be absorbed with saliva. We could further observe that also in goats portions of anti-A and anti-B antibodies could be formed which were not absorbed by saliva. Furthermore, similar experiments were performed in guinea-pigs with positive results, and in rats with negative results. In the absorption experiments preparations of carbohydrate-like nature made from saliva were also used in place of native saliva with quite the similar results.
- 千葉大学の論文
- 1955-05-28