結核患者の腸内菌叢に関する研究 : 第2編 PAS投与に依る腸内菌叢の変化に就て
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概要
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In his previous studies on the intestinal flora of far advanced tubercular patients, the author had evidenced that there existed scarcely any correlation between the general condition and the intestinal flora of patients. In the present experiments, the change in the intestinal flora of 5 tubercular patients caused by the administration of PAS (Para-aminosalicylic acid) and the antibacterial action of PAS against the coli group were investigated. A daily dose of 10 gm. of PAS to be given in 4 divided doses, was administered. for 30 days consecutively. Fourteen experiments were performed; three experiments at intervals of one week before and after the administration of the drug, and eight experiments during the administration (on the first, second, third, fifth, seventh, tenth, twentieth and thirtieth day). The following are the resulth of the experiments: 1) There was no variation in pH values of the stool. 2) The coli group showed a sudden decrease in number after the administration of the drug had begun, reaching the lowest level on the second and the third days. After that, it gradually multiplied until it reached the preadministration level on about the tenth day. 3) Unlike the coli group, the number of enterococcus began to multiply with the administration of tho drug, reaching the highest level on from the second to the fifth day. After that, it gradually was decreased until it reached preadministration level on the tenth day. 4) The lactobacillus acidophilous was also increased in number as the result, of the administration of the drug. 5) The number of living bacteria showed a tendency to decrease suddenly from the first day of the administration, reaching the lowest level on from the third to the fifth day. After that, it was gradually increased until the level attained on the first day was restored on the tenth day. Preadministration level was restored with the discontinuance of the administration of the drug. 6) The experiment in vitro has shown that the antibacterial action of PAS against the coli group is weak. It inhibited the growth of the bacteria only when it was 160 times the amount of bacteria, i.e. at the rate of 6.25 mg/cc. The antibacterial action of PAS, when it was converted to acetyl in the living body, markedly declined; it did not inhibit the growth of coli group even at the rate of 25.6 mg/cc. 7) Either one of the following conjectures might be responsible for the reduction in the number of coli group in the intestine brought about by the administration of PAS: (1) PAS might be reselected into the intestinal canal in some unknown form and show strong inhibitory action against the bacteria; or (2) the number of coli group might be decreased as a result of some .secondary reaction not by the antibacterial action of PAS itself.
- 千葉大学の論文
- 1955-03-28
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