枸櫞酸代謝に関する臨牀的研究 : 第3編 パロチンの枸櫞酸代謝に及ぼす影響

元データ 1955-03-28 千葉大学

概要

It is the established fact that citric acid is closely associated with the bone metabolism, especially the calcium metabolism, and that parotin, a hormone secreted by the salivary glands, stimulates the growth, of the bone. In order to clarify the influence of parotin on the citric acid metabolism, the author investigated citric acid levels in the serum, the urine, the stool and the bone. The following are the summary of the results of investigation : 1) The intravenous injection of parotin caused the reduction in serum citric acid levels in rabbits. 2) In the present experiments, the influence of parotin on the citric acid metabolism was investigated both in rats and children. The rats used were classified into the following four groups : the fist group to which parotin had been injected; the second group from which the salivary glands had been extirpated; the third group from which the salivary glands had been extirpated and to which parotin had been injected ; and the fourth group, the control group, which had received no treatment. At the same time, parotin .had been administered subcutaneously to normal children for several days continuously. Observations revealed that, both in rats and children, the administration of parotin brought about marked decrease in citric acid excreted in the urine, while the amounts of Ca, P and Mg excreted in the urine was also reduced, contributing to the accumulation of these substances. 3) The bone citric acid level in the epiphysis was higher than that in the diaphysis of both the femur and the tibia in rats. An investigation of thebonecitric acid levels in the femur and the tibia of the rats belonging to the four different groups as descrided above revealed that the first group manifested the highest level, while the second group showed the lowest level both in epiphysis and the diaphysis. It was further revealed that the levels of Ca, P and Mg in the bone paralleled that of citric acid in the bone.

著者

山口 一雄 千葉大学医学部小児科教室

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