抗原刺戟に対する所謂第二次反応に就いての知見補遺

概要

論文の詳細を見る
When a normal animal is inoculated with an antigen, a gradual rise of the antibody titer has been observed after a certain period of time, reaching its maximum and eventually comes down more or less slowly, although the pattern may be variable with the type of antigenic substances, the mode of inoculation, the individual difference and the physiological conditions of animals. On the other hand, if an animal previously treated with a certain type of antigen is inoculated with the same antigen, the reaction is markedly different from that of the untreated one. Using typhoid bacilli as representative of a bacterium, and influenza virus as that of a virus, the author followed the course of the so-called "secondary" and "anamnestic" reactions in rabbits. The results are summarized as follows: (1) In both cases, viz., typhoid bacilli and influenza virus, antibody titer in response to the repeated injections of an antigen rose rapidly and reached a maximum within a shorter period of time. The maximum antibody titer was higher than that of the primary reaction. (2) The decrease of antibody titer after a secondary reaction seemed to be slower than that observed in a primary reaction. (3) The so-called anamnestic reaction was observed with the above antigens, although the rise of antibody titer after a secondary heterologous stimulus was not so remarkable as with the homologous antigen.
千葉大学の論文
1955-01-28