敗血症の肺臓変化に関する病理組織学的並びに実験的研究
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概要
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In the patho-histological examination of 24 septicemia cases during 1940〜1952 the characteristic changes of the lung were observed as follows. 1) There is mainly histiocytic cell infiltration in acute septicemia in the alveolar walls and the interstitial connective tissues, histiocytic and fibroplastic in subacute, mainly fibroplastic in chronic. 2) Diffuse histiocytic cell infiltration in above mentioned area in acute septicemia should be regarded as the reaction against the bacteria circulating into alveolar capillaries, and not be simply thought of as interstitial lymphangitis or as Okabayashi's angiomesenchymal reaction. 3) Fibroplastic proliferation of the alveolar walls in chronic sepsis should be the ordinary reaction of chronic inflammations, and chronic congestion may also be an important factor. 4) Septal pneumonia, sometimes to be observed in viral diseases, diphtheria, Ekiri etc., is similar to these septic pulmonary changes in pathogenesis and should be considered as the reaction against blood circulating substances (bacteria, toxine etc.). So, in order to investigate the function of these histiocytic cells of the lungs, I inoculated hematogenously staphylococci into rabbits the lungs of which were intravitally stained by repeated intratracheal India ink injection. The results of the experiment are 1) The rabbits with stained lungs are more severely and more generally infected than the controls, and this may be due to the declined phagocytosis of the histiocytic cells in. the lung. 2) The protective mechanism of the normal lung against hematogenous bacterial infection was verified experimentally.
- 千葉大学の論文
- 1953-05-28