各種フラン誘導体特にBis-(5-nitrofurfurylidene)-acetone-guanylhydrazone hydrochloride(Panazon)の毒性に関する研究

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This paper deals with the toxicity of some furan derivatives, Panazon, 5-nitro-2-furfurylidene arninoguanidine hydrochloride and 5-nitro-2-furaldehyde semicarbazone. The experiments were undertaken so that the health problems associated with the use of these drugs as food preservatives could be properly evaluated. 1. The LD_<50> of Panazon administered orally in mice or rat was more than 5.33g. per kg., and subcutaneously above 3.75g. per kg. in mice. 2. By daily and oral administration during 6 months in rats, the minimal concentration for the appearance of histopathological symptoms was 0.1g. per kg., and none-toxic dose was 0.01g. per kg. 3. Panazon has relatively low toxicity to the isolated frog heart by Straub's method. 4. Plasma levels of Panazon were determined in rabbits and men which had received the drug by the oral route at single and repeated dosis. Maximum plasma level was obtained. at 3-4 hours after the administration. And the drug was not detected after 12-24 hours. For the estimation of Panazon in blood, a bioassay procedure introduced by Torii was used. Bis-(5-nitrofurfurylidene)-acetone guanylhydrazone hydrochloride has shown the lowest toxicity in these three furan derivatives.
千葉大学の論文
1953-05-28