難治性固形癌に対する免疫療法 : Cell TherapyからDirect Hemo-Perfusionへ(<特集>がん疾患とアフェレシス)

概要

論文の詳細を見る
Immuno-cell therapy (ICT) using cultured T lymphocytes or dendritic cells for refractory solid cancer has been actively tried clinically since the middle of the 1980's. However, it involves various problems such as an institutional standard, labor and expense to spread as a general anti-cancer treatment. Therefore, we have planned and developed a novel immunotherapeutic modality with direct hemo-perfusion (DHP) that can replace ICT. We have succeeded in developing a DHP column filled with extra-fine synthetic fibers that can adsorb immunosuppressive cytokines such as TGF-beta from the peripheral blood of advanced cancer patients or tumor-bearing rats. In addition, we have developed another DHP column filled with fibers immobilized with lipoteichoic acid that can activate blood immune cells directly. DHP with these columns can be a novel strategy of cancer immunotherapy and is expected to achieve synergistic effects with ICT or chemotherapy.
日本アフェレシス学会の論文
2009-05-31